ProTherm is a collection of numerical data of
thermodynamic parameters such as Gibbs free energy change, enthalpy
change, heat capacity change, transition temperature etc. for wild
type and mutant proteins, that are important for understanding the structure
and stability of proteins. It also contains
information about secondary structure and accessibility
of wild type residues, experimental conditions (pH, temperature,
buffer, ion and protein concentration), measurements and methods
used for each data, and activity information (Km and Kcat
ProTherm is cross-linked with sequence databases
(PIR and SWISS-PROT), structural database (Protein Data Bank), functional
database (Protein Mutant Database), and literature database (PubMed).
Moreover, the thermodynamic information
is integrated with structural and functional information through the
relational database, 3DinSight.
The WWW interface enables users to search data based on various terms
with different sorting options for outputs, and view three dimensional
structures with automatically mapped mutation sites and surrounding
amino acids. For more detail about ProTherm, please see here.
Please note that this database is under constant development. There
will be changes without prior notice. We welcome your comments and suggestions
to improve this database.